WI09MT1 - NAME BICD 100 GENETICS WINTER 2009 PROF REINAGEL...

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Unformatted text preview: NAME BICD 100 GENETICS WINTER 2009 PROF. REINAGEL UCSD MIDTERM 1 1/22/09 8:00AM — 9:10AM Full Name: Student ID: 1. This exam has 8 PAGES (4 sheets front and back). Your name must be written on EACH page. You have 70 MINUTES ( 1 hour 10 minutes) to work. . You may use pen, pencil, in any color EXCEPTred. However exams written in erasable pen or pencil are not eligible for regrades. 4. You must SHOW your work for full credit. Mistakes must be crossed out and final answer clearly indicated. 5. Write your name and student [D# on your crib sheet and turn in with use exam. Points Grade Corrections (only Prof Earned Reinagel may write in this_spaee) Page I of 8 NAME Question 1. 5 points. You begin with two purebred strains of peas P1 = purebred strain with round seeds P2 = purebred strain with wrinkled seeds You cross parental strain Pl x P2 to obtain an F1 generation. You observe that all the F1 plants have round seeds. You cross one Fl plants to another Fl plant to obtain an F2 generation. Of the F2 plants. 49 have round seeds and 23 have wrinkled seeds. (20 Invent symbols for the alleles segregating in this cross. State which is dominant and which is recessive. List all possible diploid genotypes and the associated phenotype. (b) State the genotypes of P1, P2, and the F 1 plants. (c) Use a Punnet square show how the gametes formed by the F1 plants combine to form all the possible F2 plant genotypes (d) In what ratio are the different F2 genotypes predicted to arise according to Mendel? (e) In what ratio are the different F2 phenotypes predicted to arise according to Mendel? Page 2 of 8 NAME Question 2. 5 points. Your lab has two pure-breeding strains of mice, P] and P2, but they look identical. Both strains have the same color brown fur. You perform some crosses with a somewhat surprising result. Cross 1: When you cross Ple2 you obtain F1 mice that are the same shade of brown as both of the parents. Cross 2: When you cross F leI you obtain F2 mice most of which are the same shade of brown, but some of which are white. For example in one experiment you got 7 white animals and 110 brown ones. Cross 3: when you cross Fl 3; Pl you get all brown mice. Propose a theory involving two Mendelian genes that is consistent with these results. (a) list the alleles of each gene using symbols of your own choosing. State the phenotype associated with each possible genotype in your model. (b) State the genotypes of the parents and progeny for Cross 1 Page 3 of8 NAME (c) For Cross 2 list ALL the genotypic classes among the progeny, and state their associated phenotypes. Calculate the probability of each genotypio class: using Punnet square(s) and/or probability theory. Calculate the expected frequency of white mice in this cross. (d) If you cross a white F2 with an F1 mouse, what phenotype(s) do you predict the progeny would have, and in what ratios should they occur? (If there is more than one possible F2 genotype with a white phenotype. chose any one of them to wonk out the prediction). Show yOur work. Page 4 of 8 - NAME Question 3. 5 Points Mendel claimed that his data from single factor crosses were consistent with the principles of equal segregation and random fertilization. Suppose you tried to replicate his experiment, and in one cross you obtained the following data: Cross 1: Yellow purebred x green purebred (P generation) Result: all yellow progeny (F1 generation) Cross 2: F1 x F] Result: 100 yellow, 28 green Using a Chi2 ()6) test, determine whether or not these data are consistent with his hypothesis. Show your work. Table 2-2 Critical Vu1ucs of the x* Distriimtiun Fl df 0.905 0.075 0.0 0.5 0.1 0.05 0.025 0.01 0.005 d'l' 1 .000 .000 0.015 0.455 2-706 3.841 5.024 0.635 7.1179 1 2 0.010 0.051 0.21 I 1.386 4.605 5.991 7.378 51.2 10 10.597 2 3 0.072 0.215 0.584 1366 6.251 7.5115 9.348 11.345 12.838 3 4 0.207 0.484 1.064 3.357 7.779 0.488 11.143 13.277 14.860 4 5 0.412 0.831 1.610 4.351 13.236 11.070 12.832 15.086 16.750 5 13 0.1576 [.237 2.204 5.348 10.645 12.592 14.4451 16.812 18.543 6 7 0.9119 1.690 2.833 6.346 12.017 14.067 16.013 18.475 20.278 7 8 1.344 2.180 3.490 7.344 13 .3152 15.507 17.535 20.090 21.955 8 9 1.735 2.700 4.168 8.343 14.684 10.511!) 19.023 21 .660 23.580 5} 10 2.156 3.247 4.865 9.342 15.5187 13.307 20.403 23.209 25.188 10 11 2.603 3.816 5.578 10.341 17.275 19.075 21.920 24.725 26.757 11 12 3.074 4.404 6.304 | 1.340 18.549 21.026 23.337 26.217 28.300 12 13 3.565 5.009 7.042 12.340 10.812 22.352 24.736 27.588 29.819 13 14 4.075 5.629 7.790 13.339 21.064 23.085 26.1 19 29.141 31.319 14 15 4.601 6.262 8.547 14.330 22.307 24.11011 27.488 30.578 32.801 15 —————-—____—____________________ scratch area: work here will NOT be graded: Page 5 of 8 NAME SHOW WORK HERE. FOR CREDIT: Circle one conclusion: YES the data are consistent with the predicted ratio NO the data are significantly different from the predicted ratio Page 6 of 8 NAME Question 4. 5 Points Draw a clear, unambiguous diagram of the replication and segregation of chromosomes in Meiosis, from an original diploid cell all the way to the final haploid gametes. Provide just enough detail to show how the movement of chromosomes corresponds to and explains the egg seggegation of alleles and independent assortment of genes inferred by Mendel. Use arrows and labels to point out where these principles are illustrated in your drawing. Page 7 of 8 NAME Question 5. 5 Points You track a large number of genes in a cross of two individuals of the following known genotypes: Parent 1 AaBBCeDdEEfng Parent 2 aaBchDDEengg (a) how many distinct types of gametes can Parent 1 form? (show your work) (b)how many distinct types of gametes can Parent 2 form? (show your work) (c) what is the probability that a progeny of this cross will be heterozygous for all of the genes? (show your work) (d) The genes F and G provide distinct functions both required for normal growth: either ff or gg genotype will result in a recessive dwarfism phenotype. Thus both Parent 1 and Parent 2 are dwarves. What fraction of the progeny will be dwarves‘? (show your work) Page 8 of 8 ...
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