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WI09MT1Y - NAB/1E BICDIOO GENETICS WINTER 2009 PROF...

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Unformatted text preview: NAB/1E BICDIOO GENETICS WINTER 2009 PROF. REINAGEL UCSD MIDTERM 1 1/22/09 9:30AM — 10:40AM Full Name: Student ID: we . This exam has 8 PAGES (4 sheets front and back). Your name must be written on EACH page. You have 70 MINUTES (1 hour 10 minutes) to work. . You may use pen, pencil, in any color EXCEPT red. Hewever exams written in erasable pen or pencil are not eligible for regrades. You must SHOW your work for full credit. Mistakes must be crossed out and final answer clearly indicated. . Write yOur name and student [D# on your crib sheet and turn in with exam. PagelofS NAME Question 1 . 5 points. You begin with two purebred strains of peas P1 = purebred strain with yellow seeds P2 = purebred strain with green seeds You cross parental strain Pl at P2 to obtain an Fl generation. You observe that all the F1 plants have yellow seeds. You cross one F1 plants to another F1 plant to obtain an F2 generation. Of the F2 plants. 26 have yellow seeds and 6 have green seeds. (a) Invent symbols for the alleles segregating in this cross. State which is dominant and which is recessive. List all possible diploid genotypes and the associated phenotype. (b) State the genoggpes of P1, P2, and the F1 plants. (c) Use a Punnet square show how the gametes formed by the F1 plants combine to form all the possible F2 plant genotypes (d) In what ratio are the different F2 genotypes predicted to arise according to Mendel? (e) In what ratio are the different F2 phenotypes predicted to arise according to Mendel? Page 2 of 8 NAME Question 2. 5 mints. Your lab has two pureebreeding strains of hamsters, P1 and P2, but they look identical. Both strains have the same color beige for. You perform some crosses with a somewhat surprising. result. Cross 1: When you cross PleZ you obtain F1 hamsters that are dark brown. Cross 2: When you cross leFl you obtain F2 hamsters some of which are the dark brown color of the F1, and others of which are the beige color of the parents. For example in one experiment you got 60 beige animals and 81 dark brown ones in the F2. Cross 3: when you cross F1 x Pi you get about half brown, half beige progeny. Propose a theory involving two Mendelian genes that is consistent with these results. (a) list the alleles of each gene using symbols of your own choosing. State the phenotype associated with each possible genotype in your model. (b) State the genotypes of the parents and progeny for Cross 1 Page 3 of 8 NAME (0) For Cross 2 list ALL the genotypic classes among the progeny, and state their associated phenotypes. Calculate the probability of each genotypic class‘ using Punnet square(s) andlor probability theory. Calculate the expected frequency of beige progeny in this cross. ((31) You cross beige F2 animals with F] animals. What phenotype(s) do you predict the progeny would have, and in what ratios should they occur? (If there is more than one possible F2 genotype with a beige phenotype. chose any one of them to work out the prediction). Show your work. Page 4 of 8 Using 2. Chi2 (952) test, determine whether or not these data are consistent with his hypothesis. Show your work. NAME Question 3.5 Points Mendel claimed that his data from single factor crosses were consistent with the principles of equal segregation and random fertilization. Suppose you tried to replicate his experiment, and in one cross you obtained the following data: Cross 1: Round purebred x wrinkled purebred (P generation) Table 2-2 Critical Values 1111119 x: Distribution Result: all round progeny (F 1 generation) Cross 2: F 1 x F1 Result: 88 round, 18 wrinkled d1 Lfl-thN‘ EDGENJG'H ll 12 13 14 la P [1.9515 11.975 11.9 [1.5 11.1 1.1.05 11.025 0.01 0.005 .0111] .0111) 0.1116 11.455 2.71.16 3.841 5.1124 5.635 7.879 11.11111 (1.1151 11.211 1.3116 4.5115 5.991 7.378 51.2111 111.597 (1.1172 1.1.2115 11.584 2.3515 6.251 7.815 9.3421 1 1.345 12.838 11.207 11.484 1.1164 3.357 7.7751 11.488 11.143 13.277 14.851} 0.412 11.831 1.6111 4.351 9.235 1 1.1171] 12.832 15.1186 15.7511 11.1176 1.237 2.2114 5.348 10.645 12.592 14.449 16.812 18.548 11.989 1.115111 2.833 15.346 12.1117 14.1167 16.1113 13.475 211.278 1.344 2. 11511 3.49111 7.344 13.362 15.5117 17.535 20.113111 21.955 1.735 27011 4.168 8.343 14.684 16.5119 19.023 21.1166 23.5811 2.] 51:1 3.247 4.865 9.342 15.987 18.3117 211.483 23.209 25.188 2.6U3 3.3115 5.578 111.341 17.275 19.675 21.9211 24.725 25.757 3.1174 4.4114 6.3114 11.3411 18.549 21.1125 23.337 211.21? 28.300 3.5135 5.111111 7.1142 12.3411 19.812 22.3612 24.735 27.688 29.819 4.1175 5.629 7.7911 13.339 21.064 23.1385 26.1151 251.141 31.319 4.5111 5.282 8.547 14.339 22.3117 24.996 27.488 311.578 32.801 m-t-WN—- a; masseuse 1 11 12 13 14 15 scratch area: work here will NOT be graded: Page 5 of 8 NAME SHOW WORK HERE FOR CREDIT: X2 value df P Circle one conclusion: YES the data are consistent with the predicted ratio NO the data are significantly different from the predicted ratio Page 6 of 8 NAME Question 4. 5 Points Draw a clear, unambiguous diagram of the replication and segregation of chromosomes in Meiosis, from an original diploid cell all the way to the final haploid gametes. Provide just enough detail to show how the movement of chromosomes corresponds to and explains the egg segregation of alleles and independent assortment of genes inferred by Mendel. Use arrows and labels to point out where these principles are illustrated in your drawing. Page “I of 8 NAME Question 5. 5 Points — You track a large number of genes in a cross of two individuals of the following known genotypes: Parent 1 AaBBCcDDEEffgg Parent 2 aaBchDdEeFng (a) how many distinct types of gametes can Parent 1 form? (show your work) (b)how many distinct types of gametes can Parent 2 form? (Show your work) (c) what is the probability that a progeny of this cross will be homozygous for all of the genes? (Show your work) (d) The genes A and C are redundant: you just need one dominant allele of either gene to have completely normal immune function, but the ace genotype causes a recessive immune deficiency. Thus both parents have normal immunity. What is the probability that a progeny of this cross will be immune deficient? (show your work) Page 8 of 8 ...
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