BIPN 100 pfortes

BIPN 100 pfortes - BIPN 100 [email protected] Week 1 Intro...

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BIPN 100 [email protected] Week 1: Intro to Neurophysiology Reading: pp. 132 to 136, 142-143, 160-167, 244-255 Diffusion Fick’s Law Ion Pumps Equilibrium Potentials Nerenst Equation Membrane Potentials Goldman, Hodgkin Katz Equation Organization of the Nervous System, Neurons + Glia Excitability Graded Potentials Action Potentials-Generation/Conduction/Effect of Myelin and Axon Size Synaptic Transmission Electrical Synapses(Gap Junctions) Chemical Synapses- Ionotropic, Metabotropic Neurotransmitters and Receptors Presynaptic Events: Excitatory Postsynaptic Potentials: EPSPs, Inhibitory “ “ IPSPs Neurotransmitters and Receptors Synaptic Integration: Temporal and Spatial Summation, Convergence and Divergence Models of Learning and Memory. Long Term Potentation Convergence + Divergence Central Nervous System Anatomy: Spinal Cord + Brain Grey Matter: Sensory Motor and Autonomic Interneurons
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White Matter: ascending and descending Neurons in Spinal Cord Ascending and Descending Pathways Brain Stem: Medulla, Pons, Midbrain, Cerebellum Cerebrum Cerebellum Basal Gangliea Limbic System Hippocampus, Amygdala, Cingulate Gyrus 2 Midterm exams: 20% of grade each Midterm 1: Friday Feb 1 9-9:50 am (Short Answer and Problems) Midterm 2: Friday Feb 29 9-9:50 am Final: Wed, March 19, 8-11 am Sections start next week. Section C07 WLH 2207 Midterm 1 Review Thursday 1/31 7-10 pm Peterson 110 Diffusion: higher concentration of molecules, molecules diffuse away from higher concentration As according to 2 nd law of thermodynamics: higher lower Fick’s Law: net flow or flux across a barrier driven by force and ease or difficulty of movement, in diffusion driving force is concentration gradient Ions influenced by concentration gradient and electrical field Larger the area, more flow occurs structures maximize surface area to maximize flow Permeability depends on several factors:molecular size(big slow, small fast), viscosity of medium(determined by fatty acids, state of medium), lipid solubility(cross bilayer much faster like C02, alcohol, ethanol, steroid hormones), thickness(of blood vessels prevent permeability) Net flow = driving force – area- permeability
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P = lipid solubility/ mol. Size, viscosity, thickness Carrier proteins or transporters, channels, pathways which through molecules can diffuse through the bilayer Channels: always open(leak channels), selective in charge ex. Choride selective channels, potassium channels, gated channels(available or closed): o Mechanically-touch or pressure receptors open or close depending on mechanical stimulus o Voltage- open or close depending on electrical field o Ligand- open or close depending on cell ligand o Temperature: open responding to changes in temperature ex. Cold receptors Ohm’s Law: movement of electrical charge, I= electrical field/resistance or delta V/R, conductance G, inversely proportion to R, G = 1/R Transporters carriers proteins diffusion thousands of times slower than free
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BIPN 100 pfortes - BIPN 100 [email protected] Week 1 Intro...

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