32_Ames___Aberson - 13 April 2007 Jery Stedinger Lecture 32...

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Unformatted text preview: 13 April 2007 Jery Stedinger Lecture 32 1 CEE 597 - Lecture 32 Cancer, Chemicals and Human Health 13 April 2007 Jery Stedinger Lecture 32 2 Readings Mon Abelson, Horomesis; Stolen Futures; Steingraber; Calabrese - Hormesis Wed Big risks-EPA Advisory Panel, Wildsky Morall, Review of the Record Kelman, Benefit-cost analysis Fri AIDS, Hearts and Hulley, Preventing the heterosexual spreads of AIDS 13 April 2007 Jery Stedinger Lecture 32 3 Fewer doctors urge weight loss April 20, 2004 13 April 2007 Jery Stedinger Lecture 32 4 Some extra heft may be helpful, new study says 13 April 2007 Jery Stedinger Lecture 32 5 Some unexpected findings 13 April 2007 Jery Stedinger Lecture 32 6 Comic 13 April 2007 Jery Stedinger Lecture 32 7 Exposing the threat of Dioxin Worldwide 13 April 2007 Jery Stedinger Lecture 32 8 EPA Report on Dioxins Cancer Risks 13 April 2007 Jery Stedinger Lecture 32 9 FDA: Natural risks in food outweigh man-made dangers 13 April 2007 Jery Stedinger Lecture 32 10 Trusting to Luck Trusting to Luck 13 April 2007 Jery Stedinger Lecture 32 11 How Safe is Our Food Newsweek 24 May 1993 13 April 2007 Jery Stedinger Lecture 32 12 Ames, Magaw, and Gold Ranking Possible Carcinogenic Hazards TD 50 = daily dose in mice or rats at which 50% of animals are tumor free at end of lifetime [mg/day/kg] HERP = Human Exposure/ Rodent Potency dose = Human Exposure/ TD 50 Not a direct measure of human health hazard Danger with analysis No scaling for size of animals or lifetime lengths Cancers have different mechanisms and defenses which will cause dose- response curves to have different shapes OSHA not regulating EDB for HERP of 140% but EPA bands at 0.0004% because of concern for leaching to groundwater used as a water supply and concentration in grains. EPA upper bound implies 3 cancers/1000 for uses it considered (about 1% of US cancers) (pp 275; 277) 13 April 2007 Jery Stedinger Lecture 32 13 HERP Table of Daily Human Exposure Possible Hazard TD 50 (mg/kg) 13 April 2007 Jery Stedinger Lecture 32 14 Ames et al. Conclusion Need a proper perspective. Avoid Chemophobia Natural compounds need not be benign Natural selection isnt a protection i) Cancer occurs late in life after reproductive period ii) Diets have changed iii) Natural compounds cause cancer in animals Hazard from useful chemicals generally smaller than from many natural foods (peanut butter, beer, wine, mushrooms) 13 April 2007 Jery Stedinger Lecture 32 15 Ames et al. Conclusion - Serious hazards Serious hazards tobacco (30% US cancer deaths: lung cancer + heart disease) alcohol (3% US cancer deaths) saturated fats (heart disease; colon cancer)...
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32_Ames___Aberson - 13 April 2007 Jery Stedinger Lecture 32...

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