L12 Short history of DNA


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Unformatted text preview: th http://phil.cdc.gov/phil_images/20030110/5/PHIL_2842_lores.jpg encarta.msn.com Streptococcus pneumoniae www.medicalook.com 6 7 Early evidence of genetic material “the transforming principle” 1928 - Frederick Griffith Conclusion: Living R bacteria had been transformed into pathogenic S bacteria by an unknown, heritable substance from dead S cells 8 Oswald Avery Colin MacLeod Maclyn McCarty 1. Heat killed S cells 2. Extracted carbohydrate, DNA and protein separately 3. Added extracts to R cells 4. Injected into mice 5. Which extract killed mice? 9 DNA as genetic material "If we are right, and of course that is not yet proven, then it means that nucleic acids are... functionally active substances in determining the [..] activities and [..] characteristics of cells … [Thus] it is possible to induce predictable and hereditary changes in cells. This is something that has long been the dreams of geneticists." --Oswald T. Avery, 1943 10 Is DNA or protein the genetic material? 1952 Alfred Hershey and Martha Chase “the blender e...
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This note was uploaded on 03/29/2009 for the course BIO 325 taught by Professor Saxena during the Fall '08 term at University of Texas at Austin.

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