L21 Gene mutation - Gene mutation 1 Last Time from mRNA to...

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Gene mutation 1
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Last Time from mRNA to proteins quick review: features of proteins Important components of translation machinery tRNA ribosomes Revisiting translation (with some detail) Initiation, elongation, termination 2
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Gene mutation What are mutations and how do they affect phenotype? Common mutations Causes of mutation Spontaneous and Induced 3
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Mutations likely result in detrimental effects Beneficial - mutations leading to adaptive change Neutral - have no effect on survival or reproductive success of individual Detrimental - disrupt protein function, affects survival or reproductive success 4
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Where and when a mutation occurs is important Mutations in a gene may affect specific tissue or developmental stage Germ line mutations Somatic cell mutation The stage of development during which the mutation occurs informs the range of affected cells 5
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Mutations are characterized by ability of organism to survive and reproduce Beneficial - mutations leading to adaptive change Neutral - have no effect on survival or reproductive success of individual Detrimental - disrupt protein function, affects survival or reproductive success ..but this is not always a clear cut distinction 6
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