L18 Transcription in eukaryotes

L18 Transcription in eukaryotes - Transcription in...

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Transcription in Eukaryotes http://www.mun.ca/biochem/courses/3107/images/yeast_RNAPII.gif 1
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Last Time Gene regulation overview Example of transcriptional control of gene expression: The lac operon How (and when) the lac operon is repressed How (and when) the lac operon is induced Themes in transcriptional gene regulation 2
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Transcription in Eukaryotes Overview of eukaryotic transcription Features of an eukaryotic gene: regulatory elements and transcription factors RNA processing Splicing CAP and PolyA tail modifications 3
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Eukaryotic organisms are more complex than prokaryotes http://www.harlem-school.com/10TH/sci_pdf/graphics/animal_cell.gif www.lakeshorebulldogs.com 4
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Three RNA polymerases in euks RNA polymerase I - rRNA genes (except 5S RNA) RNA polymerase II - mRNA genes (structural genes) RNA polymerase III - tRNA genes and 5S RNA 5
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Important sequence motifs in structural genes (RNAP II) regulatory sequence core promoter TATA box - specifies where RNAP should start basal level of transcription 6
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Important sequence motifs in structural genes (RNAP II) Upstream promoter element core promoter
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