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L11 Bizarre Deviants Pt2

L11 Bizarre Deviants Pt2 -...

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Bizarre Deviants Pt. 2 Epigenetics and Extranuclear inheritance http://www.willowaynurseries.com/Images/EuonymusGoldSplash.jpg 1
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Bizarre deviants! Pt1 The Maternal Effect Genetic examples Molecular basis for inheritance Maternal effect in flies Epigenetic Inheritance Dosage compensation Molecular basis for dosage compensation 2
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Genes on inactive X are not completely ‘off’ pseudoautosomal genes: Located on both Y and X Regions of homology and where sex chromosomes pair during meiosis inactive active genes here are always active 3
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Bizarre deviants! Pt2 Epigenetic inheritance Genomic imprinting Examples in human disease Extranuclear inheritance Inheritance patterns Examples in human disease Endosymbiotic Theory: chloroplasts and mitochondria 4
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Epigenetic inheritance: genomic imprinting only 1 allele is expressed (for example, only the maternal allele) in the offspring 5
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Case Study: Igf2 in mice Igf2 = normal allele Igf2 - = dwarf allele Igf2 / Igf2 - Igf2 / Igf2 - Dwarf phenotype Normal phenotype same genotype, different phenotype!!
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