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Unformatted text preview: copy of both genes to get color, genes in same pp-- pathway (not modiﬁcation) aaCNeed a wt copy of C to get color. But A modiﬁes color A-C19 --cc --cc Use of ‘knock out’ mutations to study gene function
great for determining the function of a gene! mutate gene conclusion about gene function? 20 Why might knock outs (loss of function) mutations not result in mutant phenotypes?
1. Subtle effects - many genes control phenotype 2. Mutated gene may not be always active 3. Gene is redundant 21 Paralogous genes = duplicated genes in a genome 22 Genes with redundant function 23 Summary
Gene interaction can give rise to altered F2 ratios Epistasis masks the effects of another gene Complementation of two genotypes Some genes modify the effects of other genes Paralogs may have redundant function 24 Ungraded problems Try C13, C30 Try E9, E11 25 Next Time
Linkage and genetic mapping 26...
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This note was uploaded on 03/29/2009 for the course BIO 325 taught by Professor Saxena during the Fall '08 term at University of Texas at Austin.
- Fall '08