Chem 114A 2009 lec 6 AS GIVEN 012209

Chem 114A 2009 lec 6 AS GIVEN 012209 - Since individual AT...

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Chem 114A DNA Structure and Replication Lecture 6 January 22, 2009 (Tuesday) 1
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1953 1981 Fiber diffraction of B form DNA. 14
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Structure of DNA.
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Axial view of DNA structure shows stacking of bases. 16
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Base pairs result from inter-strand hydrogen bonds. 17 GC base pair has 3 hydrogen bonds AT base pair has 2 hydrogen bonds
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Axial view of DNA structure shows stacking of bases and hydrogen bonds across the strands. 18
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Principal features of DNA structure. Two helical polynucleotide chains are coiled around a common axis. The chains run in opposite directions. The sugar-phosphate backbones are on the outside. The bases are on the inside. The bases are nearly perpendicular to the helix axis. Adjacent bases are separated by 3.4 A. The helical structure repeats every 34 A. There is a rotation of 36 degrees per turn. The diameter of the helix is 20 A.
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Unformatted text preview: Since individual AT and GC base pairs have nearly the same size, the structure is independent of sequence. 19 DNA structure discussion: see videos folder Structure of the 434 phage repressor protein bound to DNA. 21 Many weak intermolecular interactions contribute to specific amino acid sequences recognizing specific DNA sequences. Central Dogma of Biology and Information Flow. Information Flow 22 Replication: Not as simple as it seems. It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism for the genetic material. (Watson and Crick) 23 Replication. 24 Meselson-Stahl Experiment http://www.dnaftb.org/dnaftb/20/concept/index.html http://www.sumanasinc.com/webcontent/anisamples/majorsbiology/meselson.html 25 26 27 28 29 30 31 32 33 34 35 36 37 Meselson-Stahl experiment. 38 DNA replication mechanism...
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This note was uploaded on 03/30/2009 for the course CHEM 641999 taught by Professor Opella during the Spring '09 term at UCSD.

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Chem 114A 2009 lec 6 AS GIVEN 012209 - Since individual AT...

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