Aldol_I - carbon toward nucleophilic addition. Try drawing...

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The Aldol Reaction: The Base Catalyzed Aldol Process Aldehydes are good electrophiles and will readily participate in carbonyl addition reactions with nucleophiles.Enolates are good nucleophiles (recall the base promoted halogenation of ketones covered in Ch. 16). Since the enolate is “born” in the presence of the aldehyde, these two species will react Professor M. J. Krische, UT Austin
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The Aldol Reaction: The Acid Catalyzed Aldol Process Recall that protonation of the carbonyl oxygen activates the carbonyl
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Unformatted text preview: carbon toward nucleophilic addition. Try drawing the resonance structure of the protonated aldehyde above. Enols are good nucleophiles. Since the enol is born in the presence of the protonated aldehyde, carbonyl addition of the enol to the protonated aldehyde will take place. Professor M. J. Krische, UT Austin The Aldol Reaction: Aldol Products may Dehydrate upon Heating under Acidic or Basic Conditions Professor M. J. Krische, UT Austin Base Catalyzed Dehydration Acid Catalyzed Dehydration...
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Aldol_I - carbon toward nucleophilic addition. Try drawing...

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