EAS_II - Ortho/Para and Meta-Directing Groups in EAS EAS of...

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Ortho/Para and Meta-Directing Groups in EAS EAS of a mono-substituted benzene can lead to 3 different products R R E R E R E Ortho/Para-Substitution Meta-Substitution EAS E R Cl H Cl H R R H H Primary carbocation is NOT formed because it is less stable Secondary carbocation IS formed because it is more stable Recall that protonation of an alkene occurs such that the more stable carbocation is generated. Similarly, regioselectivity in EAS reactions are directed by the relative stabilities of the carbocationic intermediates. Professor M. J. Krische, UT Austin
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Ortho/Para and Meta-Directing Groups in EAS Note that para-attack of the electrophile generates a more stable carbocationic intermediate than meta-attack. For this reason, para-attack is favored. Professor M. J. Krische, UT Austin
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Note that para-attack of the electrophile generates a more stable carbocationic intermediate than meta-attack. For this reason, para-attack is favored. Professor M. J. Krische, UT Austin
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EAS_II - Ortho/Para and Meta-Directing Groups in EAS EAS of...

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