Reduction%20of%20Acyl%20Derivatives

Reduction%20of%20Acyl%20Derivatives - Reduction of Acyl...

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Reduction of Acyl Derivatives Reaction of an Ester with LiAlH 4 : An Addition-Elimination-Addition Reaction of an Amide with LiAlH 4 : An Addition-Elimination-Addition…with a twist H 3 CO C H 3 O H 3 C H 3 O Addition Elimination Tetrahedral Intermediate H 3 CH O H OCH 3 H 3 O H HO H OH H 3 O H H Addition H Al HH H AlH 3 H H AlH 3 Leaving group Nitrogen is a much worse leaving group than oxygen, which is why the mechanism for amide
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