Lecture 6 BIMM 09

Lecture 6 BIMM 09 - Quiz #1 20 points of total 200 in...

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Quiz #1 20 points of total 200 in course Selected material from Dr. Jones' lecture (pdf on course web site) will tested on the next quiz
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Genetic Imprinting Imprinting commonly serves to completely repress a gene during germ cell formation or reduce its function, and that repressed state is maintained for most of development into adulthood in somatic cells, it involves stable methylation of CG nucleotide sequences in the imprinted region Imprinting is NORMAL, but when it affects both copies of a chromosomal region in a diploid human, it can cause the human syndromes: Prader-Willi syndrome Angelman syndrome There are estimated to be between 100 and 200 imprinted genes in the mammalian genome, the phenomenon occurs only in mammals and marsupials
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maternal disomy maternal chromosomes paternal chromosome normal normal fertilized egg chromosome complement, e.g. Disomy for maternal chromosome 15 (plus a paternal 15) loss of the extra chromosome during very early embryogenesis Prader Willi human chromosome 15
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The EGFR (epidermal growth factor receptor) pathway. Another example of a receptor tyrosine kinase signaling pathway that acts through the MAPK downstream signaling pathway e.g. RAS GTPase, RAF, MEK and MAP Kinase (MAPK) EGFR When RTKs dimerize,
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Lecture 6 BIMM 09 - Quiz #1 20 points of total 200 in...

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