Lec5.2008.slides.notes - Secretory proteins are inserted...

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Unformatted text preview: Secretory proteins are inserted with different orientations into ER--- Cooper 9.9 Insertion of a IMP that spans the membrane multiple times Cooper 9.13 Insertion of a IMP that spans the membrane multiple times Alberts 12-50 Membrane Traffic Karp 8.14 Three Basic Players : Donor membrane, Target Membrane, and Transport Vesicle Three Distinct Vesicle Coats COP = coatomer pr otein Vesicle budding accomplished by COATS that surround vesicles COATS: peripheral membrane protein function as: a mechanical devise that can bend and curve a vesicle, (vesicle budding) a mechanism for selecting the cargo for the vesicle small GTPase used to regulate coating process What is the coat? Co at p roteins COP proteins: form the cytoplasmic shell engulfing membrane vesicles (At least 7 COP proteins : -cop, -cop, -cop, -cop..) Anatomy of a coated vesicle Clathr in tr iskelion Clathr in cage Clathrin coat on a membrane A characteristic honeycomb Composed of hexagons Clathrin-coated Vesicle Formation (occurs on plasma and trans-Golgi membranes) Clathrin coated vesicles form at TWO locations 1. Plasma membrane 1. TGN Golgi Adaptin: AP-1 Plasma membrane adaptin: AP-2...
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This note was uploaded on 03/31/2009 for the course BIO 320 taught by Professor Staff during the Summer '08 term at University of Texas at Austin.

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Lec5.2008.slides.notes - Secretory proteins are inserted...

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