L13.Epilepsy2

L13.Epilepsy2 - Channelopathies K and Ca2 channel mutations...

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Channelopathies- K+ and Ca2+ channel  mutations Structure of  K+ channels-ion selectivity K+ channel mutations-Benign familial  neonatal seizures Ca2+ channels and mutations –Absence  epilepsy and FHM (Familial Hemiplegic  Migraine) Interactions between channels- phenotypic  heterogeneity
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Structure of voltage sensitive K channels
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Structure of a simple bacterial K +  channel 
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   Structure of a mammalian voltage-gated K +   channel
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Kv3.2 expressed in PV+ inhibitory neurons
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Benign Familial Neonatal Seizures K+ channel mutations in two voltage gated  channels (M-type, KCNQ2, KCNQ3)-  modulated by muscarinic receptors Occur in the first year of life with onset in first  week after birth Epileptic K+ channelopathies prolong  neuronal depolarizationby showing reduced  currents  Mutations found in pore lining channels and  residues that are important for K+ ion  selectivity
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This note was uploaded on 04/01/2009 for the course BIPN 150 taught by Professor Fortes during the Winter '09 term at UCSD.

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L13.Epilepsy2 - Channelopathies K and Ca2 channel mutations...

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