L12.Epilepsy1

L12.Epilepsy1 - voltage is lower • Intracellular...

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Channelopathies-Epilepsy Characterized by episodic seizure or  abnormal brain activity (3-5 Hz) Affects 1 in 1000/2000  Julius Ceasar, Napoleon, van Gogh  Focal or generalized Spontaneous mouse mutants- epileptic  models Models for epilepsy -kindling in rodents
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Epileptic seizure-EEG
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Kindling
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Neurons Excitable cells Maintain membrane potential with intracellular 
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Unformatted text preview: voltage is lower • Intracellular potential -50 to -70 mV • Ion transporters/pumps generate the membrane potential • Ion channels use this membrane potential to generate intracellular currents Action potentials Membrane proteins that contribute to excitability Transporters Kv3.2 expressed in PV+ inhibitory neurons Affects P-type Ca channels...
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  • Winter '09
  • Fortes
  • Abnormal brain activity, mutants­ epileptic  models, Maintain membrane potential, PV+ inhibitory neurons

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L12.Epilepsy1 - voltage is lower • Intracellular...

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