L09-AD2 - 1. Review 2. Therapy (?) and ongoing/new...

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Unformatted text preview: 1. Review 2. Therapy (?) and ongoing/new strategies 1. Environmental factors, genes and AD 2. Adult neurogenesis, AD and stem cell therapy (?) http://www.alzforum.org/ http://www.nia.nih.gov/Alzheimers/ResearchInformation/ResearchCenters/ Useful websites Plaque Tangle APP and amyloid- 1. Review 2. Therapy (?) and ongoing/new strategies 1. Environmental factors, genes and AD 2. Adult neurogenesis, AD and stem cell therapy (?) Increased Synaptic Damage , Decreased Neurogenesis and Increased Amyloid Deposition in Alzheimers Disease Strategy : Increase Neurogenesis Provide Neuroprotection Decrease Amyloid load Drug targets involved in A production and assembly Beta-amyloid cleavage enzyme Increased Synaptic Damage , Decreased Neurogenesis and Increased Amyloid Deposition in Alzheimers Disease Strategy : Increase Neurogenesis Provide Neuroprotection Decrease Amyloid load A- degrading enzymes: Neprilysin Insulin degrading enzyme Endothelin-converting enzyme Plasmin Matrix metalloproteinase-9 Cysteine protease cathepsin B Thimet oligopeptidase Amyloid Neprilysin Neprilysin reduces amlyloid plaque formation Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus Henriette van Praag, Gerd Kempermann & Fred H. Gage Nature Neuroscience 2, 266 - 270 (1999) Increased neprilysin and insulin-degrading enzyme in the brain of enriched mice...
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This note was uploaded on 04/01/2009 for the course BIPN 150 taught by Professor Fortes during the Winter '09 term at UCSD.

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L09-AD2 - 1. Review 2. Therapy (?) and ongoing/new...

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