L02.ALS - BIPN 150 Lecture 2 (ALS - part I) Jan. 8, 2009...

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BIPN 150 Lecture 2 (ALS - part I) Jan. 8, 2009 Reading (see website for pdf files of articles: 1. Mitchell and Borasio article in Lancet 2. Scientific American article 3. Background reading: Chapter 16 and 17 in Neuroscience text book.
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Lou Gehrig Stephen Hawking Amyotrophic Lateral Sclerosis A-myo-trophic (greek: no muscle nurishment) Lateral sclerosis (lateral spinal column, hardening due to cell death) QuickTimeª and a decompressor are needed to see this picture.
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History and description of ALS First described in 1869 by frenchman Jean-Martin Charcot Neurodegenerative (like Parkinson’s and Alzheimer’s disease) Pathogenesis remains mysterious (many causes, speculation whether it is even a single disease). Symptoms: Unusual fatigue Muscle cramps, twitches, weakness Chewing, swallowing, breathing become difficult Usually lethal within 3-5 years of onset of symptoms Typically occurs between ages of 40-70 Locomotor functions affected, while sight, hearing, taste, smell are spared Very limited options for treating ALS at present
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This note was uploaded on 04/01/2009 for the course BIPN 150 taught by Professor Fortes during the Winter '09 term at UCSD.

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L02.ALS - BIPN 150 Lecture 2 (ALS - part I) Jan. 8, 2009...

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