Lecture-6 - A review of fate of drugs in the body...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
A review of fate of drugs in the body .
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Pharmacokinetics The quantitative description of the rates of the various steps of drug disposition, including: 1. absorption of drugs 2. distribution to organs and tissues 3. elimination by biotransformation and excretion Why is this important? 1. Allows pharmacologists to characterize in detail the fates of drugs in the body and to identify factors that determine these fates. 2. Allows physicians to calculate dosing regimens (route, dose, frequency of drug administration).
Background image of page 2
Relations among dose, plasma drug concentration and drug effect Dosage Concentration in plasma water Concentration at site of action Intensity of effect The duration of drug effects is generally related to the duration of its presence at the site of action.
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Pharmacodynamic studies investigate the intensities and time courses of the responses to drugs. DIFFICULT Pharmacokinetic studies investigate the time course of drug concentrations in blood plasma and other tissues . Question: What makes pharmacodynamic studies potentially more difficult? Active metabolites 1. Irreversibly acting drugs 2. Tolerance 3. Combinations of drugs with synergistic or antagonistic actions 4. Active metabolites
Background image of page 4
Pharmacokinetics concerns itself with models of the fates of drugs in the body. These models require verification by experimental observation .
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 16

Lecture-6 - A review of fate of drugs in the body...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online