Lecture-9 - Dose-response relationships A central question...

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Dose-response relationships A central question of drug therapy is: “What is the proper dose of a drug that will produce the desired therapeutic effect without harmful side effects”. Relationships between doses and responses are discussed in terms of log (dose) - responses (or LDR ) curves. There are threshold doses for action, as well as maximally- effective doses.
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Properties of Log (dose) - Response Curves 1. These curves describe the LDR relationship over a wide range of doses. 2. LDR curves are typically sigmoidal (“S” shaped). The middle section is approximately straight, facilitating statistical analyses. 3. The same effect is produced by different drugs that act by identical or at least similar mechanisms.
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Dose-response relationships allow one to quantitatively compare drugs. Question: How do the potencies of drugs A and B compare? A – produces a ½ max effect at a lower dosage Linear Log
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Interpreting LDR curves: receptor occupancy Drugs must attach to their sites of action (receptors) in the body in order to exert their actions. Thus the intensity of drug action is proportional to the occupancy of receptors (i.e., to the concentration of drug-receptor [DR] complexes). Response = α [DR]
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This note was uploaded on 04/01/2009 for the course BIO 51310 taught by Professor Sisson during the Spring '08 term at University of Texas at Austin.

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Lecture-9 - Dose-response relationships A central question...

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