Lecture-10 - Drug Receptors Many drugs produce their...

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Drug Receptors Many drugs produce their actions by binding to specific receptors on target cells in the body. Paul Ehrlich more than a century ago coined the term “ magic bullet ” to describe the specificity of drug action. The direct identification of receptors for drugs, hormones, and neurotransmitters began in the 1960’s with the use of radioactively-labeled compounds (ligands ) that bound with high affinities for their target sites. Biochemical and molecular biology techniques have led to the purification and molecular cloning of thousands of specific receptor genes. Examples include the sites of action of Valium, Prozac, Aspirin, opiates and marijuana.
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Nature of biological drug receptors Regardless of how they are administered, drugs interact with thousands of different proteins, lipids, carbohydrates and other chemicals in the body, but very few of these interactions elicit an effect. A
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This note was uploaded on 04/01/2009 for the course BIO 51310 taught by Professor Sisson during the Spring '08 term at University of Texas.

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Lecture-10 - Drug Receptors Many drugs produce their...

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