Drug and Alcohol Abuse Chapter 7

Drug and Alcohol Abuse Chapter 7 - Drug and Alcohol Abuse...

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Drug and Alcohol Abuse Chapter 7
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Depressants and Inhalants Depressants Early depressants Barbiturates Benzodiazepines Latest arrivals Inhalants Nitrates Solvents
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Depressants Sedatives: reduce anxiety Hypnotics: induce sleep In general decrease the CNS activity Have effects similar to alcohol
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Early Depressants Chloral Hydrate “knock out drops” or “Mickey Finn” Causes stomach upset Paraldehyde Works great, little respiratory depression Bad taste and odor Bromides Accumulate and cause depression and other significant side-effects
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Barbiturates Effective sedatives More that 2,500 produced Enhance inhibitory effects of GABA Have a wide variety in the onset of action and duration of action More lipid soluble Faster onset Shorter duration
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Barbiturates Metabolism in the liver Induces the Cytochrome P450 system Leads to tolerance Bad mix with alcohol Leads to decreased respiration Significant number of deaths
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Beneficial uses of Barbiturates Anticonvulsants (seizure meds) Effective in stopping and reducing seizures related to epilepsy Require high doses because of dependence
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Methaqualone Not a barbiturate Initially produced in India as and anti- malarial drug that failed Was a good sedative Marketed in Britain in 1965 as a sedative Huge marketing campaign was successful Widely abused by heroin users
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Methaqualone Introduced in 1965 in the U.S. Brand name was “Quaalude”
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  • Spring '09
  • Ficklen
  • Benzodiazepine, physical dependence, incoordination, inhibitory effects, beneficial uses, widely used benzo

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Drug and Alcohol Abuse Chapter 7 - Drug and Alcohol Abuse...

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