Drug and Alcohol Abuse Chapter VI

Drug and Alcohol Abuse Chapter VI - Drug and Alcohol Abuse...

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Drug and Alcohol Abuse Chapter 6
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Stimulants Cocaine Coca paste Cocaine Freebase Crack Amphetamines Ephedra Methamphetamine
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Cocaine Derived from Coca  leaves Grows in South  American Mountains  (Andes) Peru, Columbia, Bolivia Primary source is Peru Grows 6-8 feet tall Grow in small patches  called cocals Some cocals have been  used for 800 years
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Cocaine Brief history Cultivated and chewed by  ancient people of South America Used as a source of currency European explorers adopted this  currency in South America Used to increase indurance French Chemist Angelo Mariani  brewed coca wine Used in a variety of ways: drinks,  lozenges, etc
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Cocaine Brief history cont’d Initially used as a topical anesthetic Still used in some ways Freud started using it himself Promoted it as a safe energy boost Promoted it as a treatment for morphine  withdrawal Popularized in the Sherlock Holmes stories Sherlock was an addict
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Cocaine Multiple forms Leaves Coca paste Cocaine hydrochloride Freebase Crack
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Cocaine Forms Leaves Native South Americans chew the leaves Add calcified lime to increase extraction drug Coca paste Leaves are soaked with a solvent (kerosene) Liquid is drained off to form the paste South Americans mix with tobacco and smoke  it
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Cocaine Forms Cocaine Hydrochloride Salts made from the  coca paste Snorted form of cocaine Too stable to be  vaporized with heat  Can’t be smoked Freebase cocaine Extracted from cocaine  hydrochloride with ether Can be  smoked/vaporized and  inhaled
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Cocaine Forms Crack Freebase cocaine  mixed with baking  soda and water Creates a lump of  smokable cocaine AKA “rock”
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Mechanism of Action Complicated molecule Does not resemble any known n- transmitter Blocks the re-uptake 
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Drug and Alcohol Abuse Chapter VI - Drug and Alcohol Abuse...

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