Drug Use and Abuse Opioids

Drug Use and Abuse Opioids - Drug Use and Abuse Chapter 13...

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Drug Use and Abuse Chapter 13
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Opioids Derived from poppy plant (Papaver) Annual plant with large flowers Seed pods are available for a few days Shallow cuts made in the seed pod The pod weeps wipe fluid Turns brown and gummy by morning Scraped off into small balls of opium
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History Probably first used in the Middle East Used by Greeks and Romans 2-3 thousand years ago Extensive developed by Arabic physicians as alcohol was forbidden in Islam Used for centuries as a pain killer throughout the world
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Morphine Isolated in 1806 as the primary active agent in opium 10 x as potent as raw opium Still used for pain medication today Named after Morpheus, god of dreams Codeine was also derived from opium in 1832
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Morphine Advanced because: Hypodermic needle/syringe in 1853 American Civil War Given regularly in large doses to many soldiers Used for pain and dysentery Morphinism became known as “soldiers disease”
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Heroin Diacetylmorphine Two acetyl groups attached to morphine 3 x more potent than morphine More lipid soluble Enters the brain more rapidly The effects of Morphine and Heroin are identical otherwise
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Heroin Use Before the Harrison Act
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This note was uploaded on 04/02/2009 for the course HED 280 taught by Professor Ficklen during the Spring '09 term at Sam Houston State University.

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Drug Use and Abuse Opioids - Drug Use and Abuse Chapter 13...

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