CH369.lecture11.3-2-2009

CH369.lecture11.3-2-2009 - Glucose metabolism Which...

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Glucose metabolism
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Which glycolytic reactions consume ATP? A) hexokinase B) pyruvate kinase C) enolase D) A and B E) all of the above Which generate ATP?
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Glucose metabolism in context. Glycolysis gluconeogenesis
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Reactions of glycolysis. -2ATP + 4ATP _______ Net: 2ATP
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Protein Glucose fatty acid metabolism metabolism metabolism Glucose G3P Acetyl-CoA Alanine oxaloacetate Other Amino acids FA G3P Triacylglycerols Nucleic acid metabolism Pyruvate
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Glycogen (storage in liver and muscle) Glucose Brains (40-75%) Skeleton muscles, red blood cells, heart muscle Pyruvate Lactate CO2 + H2O (Citric acid cycle) Anaerobic Aerobic
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The fate of pyruvate 1. Lactate synthesis Pyruvate + NADH Lactate + NAD +
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Cori cycle QuickTime™ and a  decompressor are needed to see this picture.
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This reaction, sometimes called the eleventh step of glycolysis Glucose + 2 ADP + 2Pi 2 lactate + 2ATP
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2. Alcohol metabolism ( in yeast, etc)
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In mammals:
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3. Pyruvate as a metabolic precursor A re a c tio n tha t pro duc e s   fat  fro m  e xc e s s   c a rb o hydra te
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Pyruvate is the precursor of oxaloacetate, an intermediate of several amino acids
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Structure of biotin Biotin is a vitamin, functions as a CO 2 carrier.
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The pyruvate carboxylase reaction.
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Gluconeogenesis The pathway operates when the liver's supply of glycogen is exhausted;
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This note was uploaded on 04/03/2009 for the course CH 369 taught by Professor Kbrowning during the Spring '07 term at University of Texas.

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CH369.lecture11.3-2-2009 - Glucose metabolism Which...

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