CH369.lecture12.3-5-2009

CH369.lecture12.3-5-2009 - Chapter 11 The Citric Acid Cycle...

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    Chapter 11   The Citric Acid Cycle or Tricarboxylic acid cycle ( TCA cycle ) or the Krebs cycle
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    The citric acid cycle in context.
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    citric acid cycle Unlike a linear pathway such as glycolysis or gluconeogenesis, the citric acid cycle always returns to its starting position, therefore, presents a circular pathway .
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    citric acid cycle. Citrate synthase Aconitase Isocitrate dehydrogenase a-Ketoglutarate dehydrogenase Succinyl-CoA synthetase Succinate dehydrogenase Fumarase Malate dehydrogenase
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    § 11.1  The Pyruvate Dehydrogenase Complex  Coverts Pyruvate to Acetyl-CoA   In aerobic organisms, Pyruvate 3CO 2 Glucose Pyruvate pyruvate acetyl CoA Citric Acid cycle Mitochondria glycolysis
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    The pyruvate dehydrogenase complex  contains multiple copies of three different  enzymes  E1, E2 and E3
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    Step 1 – E1 decarboxylation reaction (TPP, Vitamin B1)
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    Step 1 – E1 decarboxylation reaction (TPP, Vitamin B1)
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    Step 2 – E2 hydroxyethyl group  oxidation reaction TPP hydroxyethyl group acetyl group
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    Step 3 – E3 acetyl-CoA  formation
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  Step 4 and 5 - restore the pyruvate  dehydrogenase complex  Step 4. Step 5
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CH369.lecture12.3-5-2009 - Chapter 11 The Citric Acid Cycle...

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