Cancer - Cancer Overview Biology of Cancer Cancer Control...

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Unformatted text preview: Cancer Overview Biology of Cancer Cancer Control Continuum What is Cancer? Cancer Morbidity and Mortality I nternational Threat of Cancer http://www-dep.iar c.fr / What is the biggest risk factor for cancer? Are genes a risk factor? ALL CANCERS ARE DUE TO CHANGES (mutations) I N GENETI C MATERI AL. What is a mutation, and how does it cause cancer? Everyone has 46 chromosomes, 23 from each parent. This is our DNA. Genes are arranged on chromosomes. I f an individual inherits a mutated copy of a gene from either par ent (a ger mline mutation) , the other gene may not function in its needed capacity (a somatic mutation)sooner or later (Knudson 2 Hit Theory for an autosomal dominant condition). Having a gene mutation does not mean that the person will develop cancer (penetrance). James Watson & Francis Crick www.cambridgephysics.com Types of Cancer Hereditary (High Risk) Early age of onset Multiple primary cancers Multiple family members affected Familial (Moderate Risk) Gene-gene interaction Gene-environment interaction Random/Somatic (Average Risk) Environmental Random changes in the gene 10% 10-30% 60-80% Types of Hereditary Cancers Breast-Ovarian...
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This note was uploaded on 04/04/2009 for the course PSYCH 531 taught by Professor Kelly during the Spring '09 term at Ohio State.

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Cancer - Cancer Overview Biology of Cancer Cancer Control...

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