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Cancer - Cancer Overview Biology of Cancer Cancer Control...

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Cancer
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Overview Biology of Cancer Cancer Control Continuum
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What is Cancer?
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Cancer Morbidity and Mortality
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International Threat of Cancer http://www-dep.iarc.fr/
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What is the biggest risk factor for cancer?
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Are genes a risk factor? ALL CANCERS ARE DUE TO CHANGES (mutations) IN GENETIC MATERIAL.
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What is a mutation, and how does it cause cancer? Everyone has 46 chromosomes, 23 from each parent. This is our DNA. Genes are arranged on chromosomes. If an individual inherits a mutated copy of a gene from either parent (a germline mutation) , the other gene may not function in its needed capacity (a somatic mutation)—sooner or later (Knudson 2 Hit Theory for an autosomal dominant condition). Having a gene mutation does not mean that the person will develop cancer (penetrance). James Watson & Francis Crick www.cambridgephysics.com
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Types of Cancer Hereditary (High Risk) Early age of onset Multiple primary cancers Multiple family members affected Familial (Moderate Risk) Gene-gene interaction Gene-environment interaction Random/Somatic (Average Risk) Environmental Random changes in the gene 10% 10-30% 60-80%
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Types of Hereditary Cancers Breast-Ovarian Colorectal Thyroid
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