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Lecture 29-The Paradox of Aerobic Life

Lecture 29-The Paradox of Aerobic Life - Lecture 29 The...

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Lecture 29- The Paradox of Aerobic Life -The paradox of aerobic life is that aerobic organisms must have oxygen, but oxygen is potentially very toxic -Ischemia- reperfusion injury: refers to damage to tissue caused when blood supply returns to the tissue after a period of ischemia (a restriction of blood supply). The absence of oxygen and nutrients from blood creates a condition in which the restoration of circulation results in inflammation and oxidative damage. Reactive Oxygen Species (ROS) O 2 + 4H+ + 4e- 2H 2 O -This reaction involves a 4 electron reduction, but you can partially reduce oxygen (one electron at a time) -Partially reduced forms of oxygen are called reactive oxygen species -ROS can be stronger than oxidizing agents than even oxygen, therefore they are very toxic to the organism as they will interfere with electron transport and ATP will not be produced O 2 + e- O 2 - (Superoxide) O 2 + 2H+ + e- H 2 O 2 (Hydrogen Peroxide) H 2 O 2 + H+ + e- H 2 O + OH (Hydrogen radical) OH + H+ + e- H 2 O
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