Lecture 001 Summary

Lecture 001 Summary - Lecture 001 Antibiotic Resistance...

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Lecture 001 – Antibiotic Resistance Antibiotic – an organic compound (containing carbon) that inhibits the growth of microbes (bacteria) through various methods. Can be either natural or synthetically made. Bacteria are prokaryotes (do not have true nucleus), and are extremely small. They reproduce exponentially, and in a short time can multiply rapidly. They have circular chromosomes. Methods from which antibiotics act: 1. Inhibiting cell wall formation 2. Inhibiting proper functioning of ribosomes (no proteins made) 3. Inhibiting DNA replication, thus unable to divide When bacteria start becoming insensitive to certain antibiotics (growth continues), it is said that the bacteria has acquired resistance to such antibiotic. Ways in which bacteria resist antibiotics: 1. Efflux pump: bacteria express gene for an efflux pump, and attached to the cell wall, the antibiotic is pumped out of the cell through the efflux pump. 2.
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