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Lecture 016 A Case For Evolutionary Thinking - Understanding HIV

Lecture 016 A Case For Evolutionary Thinking - Understanding HIV

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1 Bio1222 •MacShack contact info –post questions on WebCT boards –drop-in office hours, 2-3 pm, Mon-Thur, Staging 208 –email [email protected] for other appointment times, put 1222 in subject, UWO email account –my test questions entirely from lectures Bio1222 Major epidemics in human history Major epidemics in human history
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2 Bio1222 Human immunodeficiency virus Human immunodeficiency virus Bio1222 The African cliff The African cliff
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3 Bio1222 Outline: evolution and HIV Outline: evolution and HIV • Basic biology • Controlling HIV – Short term fixes – Long term solutions • Why are some people resistant to HIV? Bio1222 Natural history of HIV Natural history of HIV • General characteristics of viruses • Specific characteristics of HIV
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4 Bio1222 HIV HIV’ s lifecycle s lifecycle 1. attaches to host cell CCR5 receptor 2. fuses with cell 3. HIV-RNA, reverse transcriptase, integrase & protease enter cell 4. RNA Æ DNA, splice into host DNA 5. DNA Æ mRNA, mRNA Æ viral proteins 6.
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