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bicd130_06_lecture11r

bicd130_06_lecture11r - BICD 130 Embryos Genes and...

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BICD 130 Embryos, Genes, and Development
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Midterm Exam Pick-up Jackie Vignes 4334 Bonner Hall (82)2-0654 10 AM - 4 PM
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The combinatorial potential of alternative splicing The Drosophila Dscam gene can theoretically produce 38,016 isoforms Dscam (Down syndrome cell adhesion molecule) is involved in controlling axon targeting in the fl y nervous system
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Mechanisms of Differential Gene Activity Differential gene transcription Selective nuclear RNA processing Differential mRNA stability Selective mRNA translation Differential protein modi fi cation Differential protein stability
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mRNA for the milk protein casein is stabilized in the presence of the hormone prolactin t 1/2 = 28.5 hrs t 1/2 = 1.1 hrs
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The lin-4 microRNA negatively regulates accumulation of lin-14 mRNA in the worm C. elegans Bagga et al. (2005) Cell 122: 553-563
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Science 294, 853-858 (2001)
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MicroRNAs (“miRs”) encoded in the human genome
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Mechanisms of Differential Gene Activity Differential gene transcription Selective nuclear RNA processing Differential mRNA stability Selective mRNA translation Differential protein modi fi cation Differential protein stability
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Sea urchin: Ribosomes are recruited into polyribosomes after fertilization
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Sea urchin: Early protein synthesis is programmed by stored maternal mRNAs Actinomycin D is an inhibitor of transcription
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Surf clam: Masked maternal mRNA for ribonucleotide reductase (RR) Masking by inclusion in mRNP (ribonucleoprotein) particle
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A wide variety of both protostomes and deuterostomes use translational control of stored maternal mRNAs
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