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lec1 - General information Neurodevelopment BIPN 144...

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1 Neurodevelopment BIPN 144 Professor Yishi Jin 2418 Bonner Hall Office Hours - Tu 9-11 General information Course instructors: Yishi Jin & Yimin Zou Course TAs: Liseth Parra, Keith Gunapala, Keren Shahar Contact information: see syllabus (WebCT) Textbook: “Development of the Nervous System” by Sanes, Reh, Harris (2nd edition) Lecture outlines (WebCT): Powerpoint pdf Discussion sections: attendance is not mandatory, will provide problem sets and discussions 2 midterms (each is worth 25% of grade) 1 final (50% of your grade, cumulative): Mar 17 7-9:59pm No make-up exams No cell phones, pagers, allowed in lecture room General Information I. Introduction to Neurodevelopment The study of neural development draws on both neuroscience and developmental biology to describe the cellular and molecular mechanisms by which complex nervous systems emerge during embryonic development and throughout life.
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2 Major components of the nervous system Central vs. peripheral nervous system Brain Spinal cord CNS Sensory afferents Motor and autonomic efferents (motor control and neural control of organs/glands) PNS The Adult Cerebral Cortex Sherwood 2000 10 12 neurons each making 100-10,000 synaptic connections 100Xmore glia Prenatal Growth of the Human Brain After Cowan 1979
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3 Neurons are highly specialized cells S. Ramon y Cajal 1891 Neurons assume different morphology and are arranged orderly Anatomical directions DORSAL/VENTRAL:back/belly ROSTRAL/CAUDAL: nose/tail (ANTERIOR/POSTERIOR)(front/back) MEDIAL/LATERAL: midline/periphery Neural Induction Regionalization Neurogenesis Neuronal migration Specification Differentiation Axon guidance Dendritic growth Target selection Neuronal death Synapse formation Synapse refinement Experience and circuit modification Regeneration Adult neurogenesis Stem Cells Topics Covered:
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4 Logic of experimentation The major question(s) addressed by the study The methods employed to answer the
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  • Winter '08
  • Jin
  • Neural development, neural inducers, Neural Induction Regionalization, neural inducers Noggin, II. Neural Induction

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