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bicd130_06_lecture13r

bicd130_06_lecture13r - BICD 130 Embryos Genes and...

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BICD 130 Embryos, Genes, and Development
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The segmented body plan of the fl y
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The segmented body plan of the Drosophila larva is apparent at germ-band extension
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Progressive subdivision of the fl y embryo along the A/P axis depends on a cascade of transcription factors encoded by segmentation genes
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The anterior patterning system of the fl y embryo
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The posterior patterning system of the fl y embryo
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Formation of A/P protein gradients in the early fl y embryo Caudal protein
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Bicoid and Nanos establish opposing A/P gradients of Caudal and Hunchback by translational repression
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Translational repression by Drosophila Nanos
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A gradient of Bicoid protein
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Loss of bicoid function leads to loss of anterior structures
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morphogen : a concentration-dependent determinant of cell fate
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Is Bicoid a morphogen?
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Maternal Zygotic The segmentation gene cascade switches from maternal to zygotic gene expression in the very early embryo
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Sharp on/off activation of hunchback transcription by Bicoid
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Segments and parasegments
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Gap gene mutants have deletions of large multi-segment regions
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