lecture07

lecture07 - Thursday, January 27, 2005 I. Gas exchange...

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Thursday, January 27, 2005 I. Gas exchange (animals need O 2 for respiration, need to remove CO 2 as waste) A. General B. Gills C. Mammalian lung D. Mechanics of ventilation E. O 2 transport 1. Partial pressure 2. Hemoglobin (Hb) 3. O 2 binding (Fig. 48.14) a. Cooperative binding b. Graph c. Bohr effect (Fig. 48.16) d. Allosteric i. Change in one subunit affects the other subunits F. CO 2 transport 1. In tissues (Fig. 48.17a) a. CO 2 produced by tissues, diffuses into RBC b. Some CO 2 binds to Hb c. Most transported as bicarbonate d. CO 2 diffuses into blood CO 2 + H 2 O (catalyzed by carbonic anhydrase in RBC) H 2 CO 3 (carbonic acid) HCO 3 - (diffuses back into blood, eventually goes to lungs) + H + (binds to Hb) 2. In lungs (Fig. 48.17b) a. Bicarbonate into cells + H + carbonic acid CO 2 + H 2 O i. CO 2 diffuses into lungs and exhaled G. Regulation of ventilation (autonomic function) 1. Nervous system: medulla oblongata and pons (Fig. 48.20) a. Respiratory control center of brain b. Sets breathing rhythm
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This note was uploaded on 04/29/2008 for the course BIBC 100 taught by Professor Nehring during the Spring '07 term at UCSD.

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lecture07 - Thursday, January 27, 2005 I. Gas exchange...

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