hemoglobin ppt

hemoglobin ppt - But influences affinity of heme site Fig....

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Fig. 5-1 Lehn
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Fig. 5-1 Lehn
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Fig. 5-1 Lehn
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Fig. 5-1 Lehn
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Fig. 5-2 Lehn
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Fig. 5-3 Lehn
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Fig. 5-4 Lehn
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Fig. 3-13 B and T
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Fig. 5-10 Lehn
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Fig. 5-6 Lehn
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Fig. 5-7 Lehn
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Fig. 5-3 Lehn
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Fig. 3-10 B and T
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Fig. 5-10 Lehn
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Fig. 5-2 Lehn
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Fig. 5-11 Lehn
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Fig. 5-10 Lehn
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Fig. 5-10 Lehn
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Fig. 5-16 Lehn
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Fig. 5-18a Lehn
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Allosteric Modulation: BPG 2,3-bis-phosphoglycerate (BPG) binds Hb and decreases the binding affinity for oxygen BPG’s negative groups form hydrogen bonds and salt bridges in the central subunit interface of Hb and stabilize deoxy (‘T’) Binding site distinct from heme site — allosteric
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Unformatted text preview: But influences affinity of heme site Fig. 5-18b Lehn Fig. 5-18c Lehn Fig. 5-18 Lehn Fig. 3-13 B and T Fig. 5-20 Lehn Fig. 5-20 Lehn Fig. 3-14 B and T Fig. 5-20 Lehn HbS: 2 2 E6V Sickle Cell (HbS) Fiber RBC adopts sickle shape Polymerization only occurs in the deoxy (T) form sickling occurs in capillaries Sickle cells do not deform easily in transport through capillaries and rupture easily microvascular vasoocclusion and hemolytic anemia HbS increased resistance against malaria Fig. 5-19a Lehn Fig. 5-19b Lehn...
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This note was uploaded on 04/29/2008 for the course BIBC 100 taught by Professor Nehring during the Spring '07 term at UCSD.

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hemoglobin ppt - But influences affinity of heme site Fig....

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