Chapter 01 - Defining Biochemistry Biology Bi l Medicine M...

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Defining Biochemistry Biology Medicine Answers Questions & problems Chemistry 1 MCDB310 – Chapter 1: Foundations of Biochemistry
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Metabolism: Life Involves Lots of hemistry Chemistry complex biomolecules anabolism simple molecules complex biomolecules ATP [H] atabolism catabolism 2 MCDB310 – Chapter 1: Foundations of Biochemistry simple molecules
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Chemical Composition of the Human Body Dry weight of a human body consists of: arbon (C) 0% 1. Carbon (C) 60% 2. Nitrogen (N) 11% 3. Oxygen (O) 9% 4. Hydrogen (H) 6% Bulk elements: Na, K, Cl, S, Ca, P Trace Elements: Fe, Co, Cu, Zn 3 MCDB310 – Chapter 1: Foundations of Biochemistry
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Carbon central to nearly all compounds in the world >90% of the known 13 million compounds are carbon containing ( organic ) hy? arbon is very versatile Why? Carbon is very versatile 4 MCDB310 – Chapter 1: Foundations of Biochemistry
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Carbon • 4 unpaired electrons -can share them with 4 different partners an form single bonds with hydrogen can form single bonds with hydrogen • can form single and double bonds with oxygen and nitrogen 5 MCDB310 – Chapter 1: Foundations of Biochemistry
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Carbon Greatest significance: carbon - carbon bonds Single carbon-carbon bonds (e.g. in amino acids) Double and triple carbon-carbon bonds (e.g. in fatty acids): • shorter bond length • rigid, no rotation possible 6 MCDB310 – Chapter 1: Foundations of Biochemistry
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Carbon Organic compounds: Molecules with covalently bonded carbon backbones (linear, branched or cyclic) Functional Groups: roups of other atoms that are linked to carbon backbone Groups of other atoms that are linked to carbon backbone (determine physical and chemical properties) 7 MCDB310 – Chapter 1: Foundations of Biochemistry
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Functional Groups Involving Oxygen 8 MCDB310 – Chapter 1: Foundations of Biochemistry
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Functional Groups Involving Hydrogen 9 MCDB310 – Chapter 1: Foundations of Biochemistry
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Functional Groups Involving Nitrogen (e.g. His) (e.g. Arg) 10 MCDB310 – Chapter 1: Foundations of Biochemistry
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Functional Groups Involving Sulfur 11 MCDB310 – Chapter 1: Foundations of Biochemistry
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Functional Groups Involving Phosphorus Phosphoanhydride 12 MCDB310 – Chapter 1: Foundations of Biochemistry
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Amino Acids: The Building Blocks of Proteins 13 MCDB310 – Chapter 1: Foundations of Biochemistry
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The Building Blocks of Nucleic Acids 14 MCDB310 – Chapter 1: Foundations of Biochemistry
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The Building Blocks of Lipids 15 MCDB310 – Chapter 1: Foundations of Biochemistry
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he Four Classes of Biomolecules mino acids (20 different L mino acids) The Four Classes of Biomolecules 1. Amino acids (20 different L-amino acids) 2. Nucleotides (8 different nucleotides) 3. Carbohydrates (D-sugars) 4. Lipids building blocks for biomacromolecules 16 MCDB310 – Chapter 1: Foundations of Biochemistry
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Chapter 01 - Defining Biochemistry Biology Bi l Medicine M...

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