Chapter 3 students - a-(L)-Amino Acids The Building Blocks...

Info iconThis preview shows pages 1–15. Sign up to view the full content.

View Full Document Right Arrow Icon
a -(L)-Amino Acids The Building Blocks of Proteins primary amino group a -carbon 1 MCDB310 – Chapter 3: Amino General structure of an a -(L)-amino acid L-configuration carboxyl group
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 MCDB310 – Chapter 3: Amino a -Amino Acids Stereoisomerism
Background image of page 2
3 MCDB310 – Chapter 3: Amino D/L Nomenclature of Chiral Molecules
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Non-Polar Amino Acids with Aliphatic Side-Chains Leucine (L) Methionine (M) Isoleucine (I) Proline (P) 4 MCDB310 – Chapter 3: Amino Glycine (G) Alanine (A) Valine (V)
Background image of page 4
Non-Polar Amino Acids with Aromatic Side-Chains Phenylalanine (F) Tyrosine (Y) Tryptophane (W) 5 MCDB310 – Chapter 3: Amino Acids, Peptides & Proteins
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Non-Charged, Polar Amino Acids 6 MCDB310 – Chapter 3: Amino Serine (S) Threonine (T) Cysteine (C) Asparagine (N) Glutamine (Q)
Background image of page 6
Two Cys Residues Can Form a Covalent Disulfide Bond 7 MCDB310 – Chapter 3: Amino Acids, Peptides & Proteins
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Lysine (K) Arginine (R) Histidine (H) pK a = 10.5 pK a = 12.5 pK a = 6.0 Positively Charged, Polar Amino Acids 8 MCDB310 – Chapter 3: Amino Acids, Peptides & Proteins
Background image of page 8
Aspartate (D) Glutamate (E) pK a = 3.65 pK a = 4.25 9 MCDB310 – Chapter 3: Amino Negatively Charged, Polar Amino Acids
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10 MCDB310 – Chapter 3: Amino Amido vs. Carboxyl Groups Asparagine (N) Aspartate (D) Glutamate (E) Glutamine (Q)
Background image of page 10
The “21 st ” Amino Acid non-standard amino acid, required for activity of certain enzymes (e.g. thioredoxin reductases) selenocysteine codon: Normal stop-codon, but in case of selenoproteins, mRNA makes specific hairpin structure, which then allows for discrimination 11 MCDB310 – Chapter 3: Amino Acids, Peptides & Proteins
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
(collagen) (cell wall of plants, collagen) (myosin) 4 lysines (elastin) More than 250 non-standard amino acids - mostly derivatives of standard amino acids 12 MCDB310 – Chapter 3: Amino Other, Non-Standard Amino Acids (blood clotting proteins)
Background image of page 12
What amino acids are usually found in the interior of proteins (i.e., shielded from water)? What amino acids are preferentially found on the surface of proteins? 13 MCDB310 – Chapter 3: Amino Amino Acids in Proteins Hydrophobic amino acids: Gly, Ala, Val, Leu, Ile, Pro, Met, Phe, (Tyr/Trp) Polar , charged and non-charged amino acids: Ser, Thr, Cys, Asp, Asn, Glu, Gln, Lys, His, Arg, (Tyr/Trp)
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
What amino acids can form salt bridges ? What amino acids side-chains can form
Background image of page 14
Image of page 15
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 49

Chapter 3 students - a-(L)-Amino Acids The Building Blocks...

This preview shows document pages 1 - 15. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online