{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Chapter 3 students - α(L-Amino Acids – The Building...

Info iconThis preview shows pages 1–15. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: α-(L)-Amino Acids – The Building Blocks of Proteinsprimary amino groupα-carbon1MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsGeneral structure of an α-(L)-amino acidL-configurationcarboxyl group2MCDB310 – Chapter 3: Amino Acids, Peptides & Proteinsα-Amino Acids – Stereoisomerism3MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsD/L Nomenclature of Chiral MoleculesNon-Polar Amino Acids with AliphaticSide-ChainsLeucine (L) Methionine (M) Isoleucine (I)Proline (P)4MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsGlycine (G) Alanine (A) Valine (V)Non-Polar Amino Acids with AromaticSide-ChainsPhenylalanine (F) Tyrosine (Y) Tryptophane (W)5MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsNon-Charged, Polar Amino Acids6MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsSerine (S) Threonine (T) Cysteine (C)Asparagine (N) Glutamine (Q)Two Cys Residues Can Form a Covalent Disulfide Bond7MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsLysine (K) Arginine (R) Histidine (H)pKa= 10.5 pKa= 12.5 pKa= 6.0 Positively Charged, Polar Amino Acids8MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsAspartate (D) Glutamate (E)pKa= 3.65 pKa= 4.259MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsNegatively Charged, Polar Amino Acids10MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsAmido vs. Carboxyl GroupsAsparagine (N)Aspartate (D)Glutamate (E)Glutamine (Q)The “21st” Amino Acid •non-standard amino acid, required for activity of certain enzymes(e.g. thioredoxin reductases)•selenocysteine codon: Normal stop-codon, but in case ofselenoproteins, mRNA makes specific hairpin structure, which then allows for discrimination 11MCDB310 – Chapter 3: Amino Acids, Peptides & Proteins(collagen)(cell wall of plants, collagen)(myosin)4 lysines(elastin)⇒More than 250 non-standard amino acids - mostly derivatives ofstandard amino acids12MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsOther, Non-Standard Amino Acids (blood clotting proteins)What amino acids are usually found in the interiorof proteins (i.e., shielded from water)?What amino acids are preferentially found on the surfaceof proteins?13MCDB310 – Chapter 3: Amino Acids, Peptides & ProteinsAmino Acids in Proteins Hydrophobicamino acids:Gly, Ala, Val, Leu, Ile, Pro, Met, Phe, (Tyr/Trp)Polar,charged and non-charged amino acids:Ser, Thr, Cys, Asp, Asn, Glu, Gln, Lys, His, Arg, (Tyr/Trp)What amino acids can form salt bridges?...
View Full Document

{[ snackBarMessage ]}

Page1 / 49

Chapter 3 students - α(L-Amino Acids – The Building...

This preview shows document pages 1 - 15. Sign up to view the full document.

View Full Document Right Arrow Icon bookmark
Ask a homework question - tutors are online