Chapter 16 notes - The Citric Acid Cycle A metabolic hub...

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The Citric Acid Cycle A metabolic hub
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Role of the Citric Acid Cycle in Metabolism 2 MCDB310 – Chapter 16: Citric Acid Cycle Catabolic role of CAC: Receives products from catabolic reactions (glycolysis, break-down of fatty acids and amino acids) as acetyl-CoA Oxidizes these products to CO 2 ( some ATP) Electrons are transferred to respiratory chain ( lots of ATP ) Anabolic role of CAC: Intermediates of CAC are important precursors in many biosynthetic pathways Metabolic hub ( amphibolic pathway )
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The Citric Acid Cycle: Overview 3 MCDB310 – Chapter 16: Citric Acid Cycle Cyclic pathway localized in the mitochondrion of eukaryotic cells (bacteria: cytosol) Carbon enters cycle as C 2 (Ac-CoA) C 6 2 oxidative decarboxylations: Carbon leaves cycle as CO 2
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Acetyl-CoA as a Key Metabolite 4 MCDB310 – Chapter 16: Citric Acid Cycle Amino acids Ac-CoA Fatty acids Citric acid cycle Carbohydrates
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Formation of Ac-CoA from Pyruvate 5 MCDB310 – Chapter 16: Citric Acid Cycle Pyruvate from glycolysis is transported into mitochondria Oxidative decarboxylation by multi-enzyme pyruvate dehydrogenase complex Advantage: substrate channeling, coordinated regulation G’ 0 = -33 kJ/mol
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The Pyruvate Dehydrogenase Complex 6 MCDB310 – Chapter 16: Citric Acid Cycle
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The Pyruvate Dehydrogenase Complex 7 MCDB310 – Chapter 16: Citric Acid Cycle 1. TPP cofactor of E 1 accepts hydroxy-ethyl group from pyruvate, CO 2 is cleaved off (cf. pyruvate decarboxylase in ethanol fermentation) 2. Hydroxyethyl group is transferred by E
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This note was uploaded on 04/05/2009 for the course MCDB 310 taught by Professor Walter during the Spring '09 term at University of Michigan.

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Chapter 16 notes - The Citric Acid Cycle A metabolic hub...

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