Lecture17

Lecture17 - Nutrition and Cancer Cheryl L. Rock, PhD, RD...

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Unformatted text preview: Nutrition and Cancer Cheryl L. Rock, PhD, RD Dept. of Family and Preventive Medicine Cancer Prevention and Control Program University of California, San Genet ic Chan ge Body Surface Deactivation Activa tion Nucleus Excreti on Genetic Change Genetic Change Genetic Change Selectiv e Clonal Expansi on Defects in Terminal Differentiation Defects in Growth Control Resistance to Cytotoxicity Activation of Proto-Oncogenes Inactivation of Tumor Suppressor Genes Inactivation of Antimetastasis Genes Initiation Promotion Conversion Progression NORMAL CELL INITIATED CELL PRENEOPLASTIC LESION MALIGNANT TUMOR CLINICAL CANCER CLINICAL CANCER Inhibition Harris CC. 1991 Nutrition and Cancer Cancer etiology is multifactorial both genetic susceptibility and a variety of environmental factors determine risk Accumulated evidence suggests that approximately 30-40% of cases are potentially preventable by modifying food choices and nutritional factors Disentangling effects of various foods, specific dietary constituents and related lifestyle factors (e.g., obesity, physical activity) is challenging Interpreting Studies and Media Reports on Nutrition and Cancer Types and sources of information Epidemiological studies: Ecologic, case-control, cohort Animal and laboratory studies Anecdotal reports Clinical trials of varying quality, designs, and outcomes Problems with the Traditional Approach Isolated food components Potential synergy and context of consumption Formulation Animal models Differential uptake and metabolism Cell culture studies Context of intact biological system Differential cell functions and carcinogenic process Bioactive Food Components and Cancer Risk and Progression Nutrients: Vitamins, minerals Carotenoids Flavonoids Organosulfur compounds Isothiocyanates Indoles Monterpenes Phenolic acids Proposed Mechanisms Antioxidant activity Effects on cell proliferation, differentiation, and apoptosis Enzyme induction or inhibition and detoxification Effects on immune function Effects on angiogenesis, and cell adhesion and invasion Regulation of hormone metabolism Antibacterial and antiviral effects Milner JA. J Nutr 2004; 134:2492S. Beta-Carotene Supplement Trials Consistent associations between dietary intake, circulating beta-...
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This note was uploaded on 04/29/2008 for the course BICD 120 taught by Professor Crawford during the Spring '06 term at UCSD.

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Lecture17 - Nutrition and Cancer Cheryl L. Rock, PhD, RD...

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