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Doublehelixlecture2.ppt", filename="Doublehelixlecture2.ppt", filename="Doublehe

Doublehelixlecture2.ppt", filename="Doublehelixlecture2.ppt", filename="Doublehe

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1 Watson & Crick, Lecture 2 Three W& C models of DNA One model by Pauling
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2 Questions 1. Describe Linus Pauling's 1951 alpha helix for proteins 2. Describe W&C's 1951 model of DNA how many strands? where bases? how held together? what problem? 1. Describe W&C's first 1953 model (never built model; just Waston's idea) 2. Describe W&C's published 1953 model for DNA
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3 Nucleic Acids vs. Proteins Proteins elements: carbon, hydrogen, oxygen, nitrogen, sulfur amino acids (strings called "polypeptides") protein: one or more polypeptide chain Nucleic Acids elements: carbon, hydrogen, oxygen, nitrogen, phosphorous DNA deoxyribose sugar, phosphates, bases bases: A, T, G, C RNA ribose sugar, phosphates, bases bases: A, U, G, C
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4 Linus Pauling α (alpha) helix Discovered in 1951 How many strands? one What shape? helix Composed of what? amino acids (this is a protein!)
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5 History of Discovery of Double Helix of DNA in 1953 Background protein view of life: gets disproved tetranucleotide hypothesis (amounts of 4 bases equal): Chargaff disproved (1950)
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