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Blood - Blood OBJECTIVES List the major components of...

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Blood OBJECTIVES: List the major components of blood ( read fxns of blood in text ) Discuss red blood cell structure and oxygen carrying function Discuss ABO blood types Briefly describe the various white blood cells and their functions Briefly describe platelets Discuss blood clotting
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Blood Major Components 1. 1. 2. 2.
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Blood Plasma NOTE: Serum is plasma without clotting proteins 1. 1. Most of these proteins are made by the liver
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Blood Formed Elements (cells and cell fragments) 2. 2.
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Red Blood Cells Also called RBC’s or erythrocytes
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Red Blood Cells Most oxygen in blood carried by RBC’s Can do this because they contain the protein HEMOGLOBIN HEMOGLOBIN Each protein contains 4 HEME HEME molecules Each heme molecule contains an IRON IRON atom binds to oxygen Clinical Note: Oxygen Saturation (or O 2 sat.) Measure of the percentage of hemoglobin binding sites in the bloodstream occupied by oxygen 95-100% is normal Below 90% = serious HYPOXEMIA Measured easily with pulse oximeter
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Overview of RBC lifecycle Made in Red Bone Marrow Circulate for approx 4 months Old RBC’s recycled by cells in liver,spleen and marrow Heme molecule broken down to bilirubin bilirubin (yellow-orange pigment) excess causes Jaundice Bilirubin Bilirubin dumped into intestines, converted to urobilins (yellow) & stercobilins (brown) which are eliminated in urine and feces Iron reused Stimulated by Erythropoietin Erythropoietin (EPO) [ hormone made by kidney ]
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