Lecture 15 Cell Cycle and Cancer Notes

Lecture 15 Cell Cycle and Cancer Notes - Cell-Cycle...

Info iconThis preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
Cell-Cycle Regulation and the Cell-Cycle Regulation and the Genetics of Cancer Genetics of Cancer Learning Objectives 1. Describe the normal control of cell division. 1. Normal cell cycle 2. Molecular signals 3. Machinery 4. Checkpoints that regulate passage through cell cycle 2. Explain how cancer arises from malfunctions in controls over cell division 1. Description of cancer phenotypes 2. Analysis of clonal nature of tumors Bert Vogelstein & Kenneth W Kinzler. 2004. Nature Medicine  10:789
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Current Research on Campus Charles M Perou gene expression-defined cancer subtypes for breast cancer using microarrays/gene chips Carolyn I Sartor epidermal growth factor receptor (EGFR) family in breast cancer development and response to radiotherapy. Albert Baldwin regulation and functions of the transcription factor NF-kB and the role of NF-kB in tumorigenesis and resistance to cancer therapy James Swenberg role of DNA damage and repair; developed ultra- sensitive and highly specific MSmethods for measuring the DNA and hemoglobin adducts William Kaufman Cell cycle checkpoints and repair of DNA damage before replication Oliver Smithies correction of genes with mutant pathologies (gene
Background image of page 2
Challenges for Cancer  Genetics 1. the discovery of new genes that have a  causal role in neoplasia (initiation and  progression) 2. pathways through which these genes act  and the basis for the varying actions in  specific cell types. 3. development of new ways to use this  knowledge for the benefit of patients Vogelstein and Kinzler, Nature Med 10:789 (2004)
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Nature Reviews Cancer   4 , 177-183 (2004); doi:10.1038/nrc1299 A CENSUS OF HUMAN CANCER GENES Mutations in Cancer Can Act in a 
Background image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 30

Lecture 15 Cell Cycle and Cancer Notes - Cell-Cycle...

This preview shows document pages 1 - 5. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online