{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Lecture 15 Cell Cycle and Cancer

Lecture 15 Cell Cycle and Cancer - Cell-Cycle Regulation...

Info icon This preview shows pages 1–5. Sign up to view the full content.

View Full Document Right Arrow Icon
Cell-Cycle Regulation and Cell-Cycle Regulation and the Genetics of Cancer the Genetics of Cancer Learning Objectives 1. Describe the normal control of cell division. 1. Normal cell cycle 2. Molecular signals 3. Machinery 4. Checkpoints that regulate passage through cell cycle 2. Explain how cancer arises from malfunctions in controls over cell division 1. Description of cancer phenotypes 2. Analysis of clonal nature of tumors 3. Explanation of mutation in protooncogenes
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
The normal cell division Cyclin- dependent kinases collaborate with cyclins to ensure the proper timing and sequence of cell-cycle events. The cell cycle has four phases: G , S G , and M. 19-2 Fig. 19.2
Image of page 2
Normal gene product must be produced  at a particular stage in the cell cycle. Cell acquires ability to complete a cell cycle the moment the temperature-sensitive protein has fulfilled its function in that cycle. CDC28 gene is the first step in cell cycle. After CDC28 step, cell is committed to finish cell cycle. Alternative fates after first cell cycle: Arrest of cell division Fusing with a cell of opposite mating type Decision to pursue made in G 1 phase at “start” 19-3 Fig. 19.6
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Cyclin-dependent kinases (CDK) control the  cell cycle by phosphorylating other proteins.
Image of page 4
Image of page 5
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}