Lecture 15 Cell Cycle and Cancer

Lecture 15 Cell Cycle and Cancer - Cell-Cycle Regulation...

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Unformatted text preview: Cell-Cycle Regulation and Cell-Cycle Regulation and the Genetics of Cancer the Genetics of Cancer Learning Objectives 1. Describe the normal control of cell division. 1. Normal cell cycle 2. Molecular signals 3. Machinery 4. Checkpoints that regulate passage through cell cycle 2. Explain how cancer arises from malfunctions in controls over cell division 1. Description of cancer phenotypes 2. Analysis of clonal nature of tumors The normal cell division • Cyclin- dependent kinases collaborate with cyclins to ensure the proper timing and sequence of cell-cycle events. – The cell cycle has four phases: 19-2 Fig. 19.2 Normal gene product must be produced at a particular stage in the cell cycle. • Cell acquires ability to complete a cell cycle the moment the temperature-sensitive protein has fulfilled its function in that cycle. • CDC28 gene is the first step in cell cycle. – After CDC28 step, cell is committed to finish cell cycle. – Alternative fates after first cell cycle: • Arrest of cell division • Fusing with a cell of opposite mating type • Decision to pursue made in G 1 phase at “start” 19-3 Fig. 19.6 Cyclin-dependent kinases (CDK) control the cell cycle by phosphorylating other proteins....
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This note was uploaded on 04/05/2009 for the course BIOL 202 taught by Professor Kieber-hogan during the Spring '08 term at UNC.

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Lecture 15 Cell Cycle and Cancer - Cell-Cycle Regulation...

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