Lecture 16 Genetic Mapping

Lecture 16 Genetic Mapping - Announcements 2/20 Problem set...

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Announcements 2/20 Problem set 3 due tonight Quiz 5 and Problem set 4 will be posted over the  weekend. Exam review to be scheduled Bring scantrons to exam.
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Genetic mapping in diploid organisms Learning Objectives 1.  Map gene distances and linkage relationships using two-  and three- point crosses 2.  Explain the limitations of two-point crosses and the  advantages of three-point crosses 3. Calculate corrections for multiple crossover events 4. Calculate the coefficient of coincidence and chromosomal  interference for double crossovers 
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How do we determine the position  of genes on chromosomes?
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How do researchers develop a map? Genomes can be mapped at varying levels of resolution Linkage Restriction cleavage DNA sequence Commonly used genetic markers RFLPs , or restriction fragment length polymorphisms  VNTRs , or variable number of tandem repeat polymorphisms  Microsatellite polymorphisms,  variable number of repetitions of a  very small number of base pairs within a sequence SNPs , or single nucleotide polymorphisms
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Page 143 Gene mapping  may lead  to cure for  Cystic Fibrosis Determined that CF caused by a  single gene using family pedigrees Found genetic marker D7S15 that  cosegregate with the mutant CF gene 
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Lecture 16 Genetic Mapping - Announcements 2/20 Problem set...

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