Lecture 23 Eukaryotic Txn

Lecture 23 Eukaryotic Txn - Eukaryotic Transcripti on...

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Eukaryotic Transcription Dr. Matera 18 Mar 2009 Structural similarity between a bacterial RNA polymerase and a  eukaryotic RNA polymerase II. Regions of the two RNA  polymerases that have similar structures are indicated in  green The eucaryotic polymerase is larger than the bacterial enzyme (12  subunits instead of 5), and some of the additional regions are  shown in gray. The  blue   spheres  represent  Zn  atoms that serve  as structural components of the polymerases, and the  red sphere   represents the  Mg  atom present at the active site, where  polymerization takes place.  From Alberts et al., Fig. 6-15
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Common Ancestor The Tree of Life: The lengths of the branches on the tree reflect how much the DNA of each  lineage has diverged from its common ancestor. The branches demonstrate that most of  life's genetic diversity turns out to be microbial. Thermococcus
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Bacterium Animal cell Major differences between prokaryotic and  eukaryotic  cellular organization
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Major differences between prokaryotic and  eukaryotic  gene expression 1 RNA polymerase 4 Mb genome, >50% coding ~4000 genes 3 RNA polymerases; chromatin 3000 Mb genome, 1.5% coding ~20,000 Genes, 3 m per cell;  300Bkm
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Three eukaryotic RNA polymerases TYPE OF POLYMERASE GENES TRANSCRIBED RNA polymerase I 5.8S, 18S, and 28S rRNA genes
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Lecture 23 Eukaryotic Txn - Eukaryotic Transcripti on...

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