Lecture 25 Translation

Lecture 25 Translation - Translation and Translation al...

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Translation and Translational Control Dr. Matera 23 Mar 2009 The large subunit of the ribosome is an  “RNPzyme,” wherein the RNA forms the  active site, but proteins are critical co- factors (image courtesy of T. Cech).
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C H O H C R O N H H amino group NH - side chain carboxyl group -COOH α carbon All amino acids (peptides) have the same  core structure Proteins (also called polypeptides) are formed from chains of linked amino acids. The side chains give each amino acid it’s “personality”
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As with nearly all biological processes that involve nucleic acids, base pairing interactions play a key role in the translation of genetic information from mRNA into protein. Central Dogma
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Transfer RNAs serve as adaptor molecules ? CH 3 CH COOH H 2 N CH 2 CH 2 S methionine C A U tRNA Met anticodon mRNA A U G start codon How do we know that basepairing is key?
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methionine C A U tRNA Met anticodon methionine aminoacyl tRNA synthetase ATP C A U charged tRNA CH 3 CH C H 2 N CH 2 CH 2 S O O CH 3 CH C H 2 N CH 2 CH 2 S OH O AMP + PP i There are 20 aminoacyl tRNA synthetases in the cell,  one for each amino acid!
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This note was uploaded on 04/05/2009 for the course BIOL 202 taught by Professor Kieber-hogan during the Spring '08 term at UNC.

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Lecture 25 Translation - Translation and Translation al...

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