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class notes and powerpoints - Utilizes both glycolytic and...

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Unformatted text preview: Utilizes both glycolytic and oxidative pathways Liver cell ( hepatocyte) functions: Carbohydrate, lipid and amino acid procesSlng Detoxification and removal of wastes, toxins, and old or damaged cells Synthesis of proteins Storage of metabolic products, vitamins and minerals Can produce glucose from other biological compounds ( gluconeogenesis ) Lactate dehydrogenase converts lactate 1nto pyruvate Pyruvate 1S the substrate of oX1dat1ve metabol1sm Slow contraction velocity (twitch) Highly fatigue-resistant Large number of mitochondria High myoglobin content Extensive capillarity Reddish in color Uses the oxidative pathway- \ ~- ~ : . i Fast contraction Velocity (twitch) Moderate fatigue resistance Large number of mitochondria High myoglobin content High capillarity Reddish color Oxidative-glycolytic pathway Fast contraction velocity (twitch) Low fatigue resistance Few mitochondria Low myoglobin content Minimal capillarity White in color Glycolytic pathway t ActiwtiOll E"ergy (f""j-flOl'ICYIn(' ~'~ .. Actil'diotlEllergy .~.~ .. . J_.. jl:-:~,L::__ ~.~~.':.~'!:I!!."!. . , v , \' '. I j \, \, " , \ Increases in temperature increases reaction rate Each enzyme has an optimal temperature range Biological enzymes will denature when exposed to temperatures above normal physiological conditions Enzyme is not consumed in the reaction ESt)E+P rate (velocity) is directly proportional to the # of ES interactions per unit time Inhibitors are non -substrate molecules that decrease enzyme activity Inhibitor binding in active site prevents substrate binding Inhibitor binding (in allosteric site) causes change in active site shape to prevent substrate binding Product of reacti.on acts as an inhibitor to prevent over-production _ / I : ; : / t Glycolytic pathway (glycolysis) supplies Z ATP per molecule of glucose T .-l "t-v :-." ,."1 ,~,." f ... .. Oxidative pathway (Krebs cycle and electron transport chain) supplies 38 APT per glucose mol ,. (iLY< '( )LYSIS ' \ " 'l'" I1 ',('T n C 1 d rl l' < ;P ,I(1' ')I L~'::,b\iMii"\ ,k" :t2''''''lr' matrix mrtocboncmo Soleus- Type I (slow oxidative) skeletal muscle Vastus- Type II (fast glycolytic) skeletal muscle Liver- both glycolytic and Cardiac- highly oxidative Brain- highly oxidative "slow twi tch" for stubili.ty or aerobi.c activities "fast twitch" for powerful and anaerobic activlties Muscles of Ventilation Diaphragm - primary muscle of inspiration External Intercostals- assistor muscle of inspiration Sternocleidomastoid and Scalenes - weak assistor muscles of inspiration Internal Intercostals - assistor muscle of expiration Abdominal muscles - weak assistor muscles of expiration Muscles of Ventilation SI",r"0C 'te.oc-n., stc.d $:;;.111;"',5 90 " 70 11 6 0 12 50 30 10 P A c id (H I 40 T em per aturc 0 ' 2 .3 8 js p tlO ~ p h u q ly c e lilk ' 30 10 :;.00 30 10 SO 60 70 no 00 100 Lung Volumes cont'd...
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class notes and powerpoints - Utilizes both glycolytic and...

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