Hasselmo & Stern Article

Hasselmo & Stern Article - Hasselmo & Stern...

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Brain mechanisms underlying working memory for novel information include a buffer in parahippocampal cortices. Electrophysiological data suggest that the buffer for novel information depends on acetylcholine. Acetylcholine activates single-cell mechanisms that underlie persistent spiking of neurons in the absence of synaptic transmission, allowing maintenance of information without prior synaptic modification. Novel Stimuli Familiar Stimuli Structures Pre-frontal cortex Parietal cortex Parahippocampus Pre-frontal cortex Parietal cortex Findings Although cortical regions including prefrontal cortex and parietal cortex show activity during working memory for novel stimuli, these regions do not seem to be sufficient to perform working memory for novel stimuli at normal levels when parahippocampal regions are lesioned, Areas outside of the parahippocampal region seem to be sufficient for normal delayed matching function with small numbers of highly familiar stimuli , but are not sufficient to support normal working memory for novel stimuli after parahippocampal lesions. Cortical regions are sufficient to maintain normal working memory for familiar stimuli. Parahippocampal lesions in humans also
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This note was uploaded on 04/08/2009 for the course PS 333 taught by Professor Otto during the Spring '09 term at BU.

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Hasselmo & Stern Article - Hasselmo & Stern...

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